Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
نویسندگان
چکیده
منابع مشابه
A Rationalized Description on Study of Intestinal Barrier, Drug Permeability and Permeation Enhancers
Per oral delivery of hydrophilic drugs is one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. In the last few years great interest has focused on search of different intestinal permeation enhancers for the oral delivery of BCS class iii drugs, small polar molecules, vaccin...
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Drug-in-adhesive patches (DIAPs) of fentanyl were formulated using various pressure sensitive adhesives (PSAs) and various chemical permeation enhancers (CPEs). The effects of PSAs and CPEs on skin permeation of fentanyl from DIAPs were evaluated using modified jacketed Franz diffusion cells fitted with excised rat abdominal skin. It was demonstrated that the permeation rate or steady state flu...
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Certain agents that enhance drug transport through the skin, including surfactants, bile salts, and fatty acids, have been shown to exert a similar effect on the oral mucosa. Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single ...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2020
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12030242